Endothelial nitric oxide synthase and cardiac remodelling: location, location, location?
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چکیده
منابع مشابه
Endothelial nitric oxide synthase and cardiac remodelling: location, location, location?
Left ventricular hypertrophy (LVH) in response to an increased systolic load is a compensatory mechanism that aims to restore LV pump function to normal levels. Clinically, chronic systolic LV overload most commonly results from myocardial infarction (MI), or chronic pressure overload, including hypertension and aortic stenosis. Despite the apparent appropriateness of the hypertrophy process, L...
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Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
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Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 0008-6363
DOI: 10.1093/cvr/cvs021